The thermal performance and life cycle assessment (LCA) analysis of the popular multilayered envelope assemblies of the low-storey dwelling segment was performed. Five commonly used and appropriate “cost-quality” assemblies of the Ukrainian construction market were researched in a case study. The bullet point of the research was to figure out the “optimal” assembly type in terms of Global Warming Potential (GWP) (kg CO₂ equ./m²), internal heat area capacity (kJ/m²K) as dynamic thermal characteristic, u-value (W/m²K) and the mass of the wall kg/m² as the steady state physical characteristics. These five types of multilayered wall assemblies, which were compared, are brick wall masonry insulated, D300 aerated concrete insulated, cavity brick wall masonry insulated, SIP wall as a quick construction system and strawbale wall in the type of structural timber frame with inner infill as more expensive natural building material. The Eco2soft tool and Excel spreadsheet for thermal mass calculus according to EN ISO 13786 were used for current research. Research revealed that assessing different criteria is still challenging for Multicriteria Decision Analysis (MCDA).